Barupal Research Foundation

Foundation's research focuses on ideas that would improve indicators in health energy and agriculture sectors.

Exposome

The totally of exposures to human body is defined as the exposome by Prof Christopher P. Wild, Director, International Agency for Research on Cancer (IARC), World Health Organization. In parallel to genome wide association studies (GWAS), which have successfully identified a range of genetic loci that are implicated in human diseases, the exposome-wise association studies (EWAS) would identify the preventable exposures that are major contributors to diseases attributed worldwide mortality. Pollutions in air, water and food would be characterized and their contributions in etiologies of diseases would be distangled by analyzing blood-specimens in case-control designs.

Bioinformatics

With the emergence of omics methods, it is now possible to create data matrices which can have thousands of variables measured in a single sample. On epidemiological scale, where sample sizes can easily in 1000s, new tools are required to process, store, analyze and interpret the raw data produced by omics methods. Foundation's scientific team collaborates with eminent scientists in the fields to work on projects which would lead to creation of new bioinformatics approaches for such large-scale omics investigations.

Agriculture and biofuel

Abiotic stress is a leading cause of loss in productivity of standing crops. Foundation set-up projects on utilizing publicly available datasets on plants in order to understand the abiotic stress resistance mechanisms, which can lead to identification of biochemical pathways that can be modified to confer the resistance mechanisms in the crops of global food basket. On biofuel research, projects are being initiated on screening of algal strains which can produce higher content of lipids that can be used a biofuels. Further, the selected strain would be subjected to predictive modeling using omics datasets for scaling up to the bioreactor level.